Metformin is indicate in the treatment of –

  • To decrease hepatic glucose production, and glucose absorption in the GIT.
  • To increase target cell insulin sensitivity.


  • Metformin 500mg


  • Immediate release tablet:
  • Initial: 500mg every 12hrs or 850mg daily with meals.
  • Increase dose in increments of 500mg/week or 850mg/2weeks depending on glycaemic control and tolerability.
  • Maintenance: 1500-2550mg/day in two or three divided doses with meal.
  • Max. 2550mg/day.
  • Extended-release tablet: 500mg daily with dinner, titrate with 500mg/day every week, not to exceed 2000mg/day.